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KMID : 1003920060150010070
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Journal of Traditional Korean Medicine
2006 Volume.15 No. 1 p.70 ~ p.76
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Inhibitory Effect of the Ethanol Extract of Fagopyrum escuentum on Melanin Synthesis
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Kim Dae-Sung
Roh Seong-Taek
Lee Jang-Cheon
Lim Kyu-Sang
Shin Mee-Ran
Woo Won-Hong
Mun Yeun-Ja
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Abstract
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The aim of this study was to investigate the effect of ethanol extract of Fagopyrum escuentum(FE) on the melanogenesis. To determine whether ethanol extract of FE suppress melanin synthesis in cellular level, B16F10 melanoma cells were cultured in the presence of different concentrations of FE ethanol extract. In the present study, the author examined the effects of FE ethanol extract on cell proliferation, melanin contents, tyrosinase activity. Cell proliferation was slightly increased by treatment with ethanol extract of FE (25-200 g/ml). The ethanol extract of FE effectively suppressed melanin contents at a dose of 100 g/ml. It was observed that the color of cell pellets was totally whitened compared with the control. The ethanol extract of FE inhibited tyrosinase activity, regulate melanin biosynthesis as the key enzyme in melanogenesis. These results suggest that the ethanol extract of FE exerts its depigmenting effects through the suppression of tyrosinase activity. And it may be a potent depigmetation agent in hyperpigmentation condition.
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KEYWORD
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Fagopyrum escuentum, melanin, tyrosinase, depigmentation
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